a. The exclusion of patients with M1 disease is not intended to imply that mastectomy and immediate reconstruction is not a valid treatment option for patients with metastatic disease. The development group recommend that all patients are discussed on an individual basis to determine the most appropriate treatment.
b. Triple negative breast cancers are cancers that have tested negative for oestrogen receptors ( ER-), progesterone receptors ( PR-) and HER2 ( HER2-) receptors.